• Tab. Valprol CR-500mg

Tab. Valprol CR-500mg

Requires Prescription
strip of 15 tablets
Generic Name: Sodium Valproate + Valproic Acid
25 Ratings
Rs. 227.1

Additional Information

No Additional Information

Information about Tab. Valprol CR-500mg

Valprol CR Tablet is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Valproic acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is also a histone deacetylase inhibitor. Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV to remain in infected cells.


Sodium Valproate (333mg) + Valproic Acid (145mg)


Valprol CR is used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia.

Direction to Use

  • Take this medicine in the dose and duration as advised by your doctor.
  • Swallow it as a whole. Do not chew, crush or break it.
  • Valprol CR Tablet is to be taken with food. Valprol CR Tablet should be taken at the same time every day to maintain consistent levels in your body.
  • Do not stop using Valprol CR Tablet without talking to your doctor, even if you feel better.
  • Avoid consuming alcohol when taking Valprol CR Tablet, as it may cause excessive sleepiness or drowsiness.

Side Effects

Common Side Effects of Valprol CR are Loss of appetite, Nausea, Vomiting, Sleepiness, Hair loss, Weight gain, Liver function abnormal, Tremor.

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