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Mizest contains Mirtazapine as the active ingredient which is a noradrenergic and specific serotonergic antidepressant used in the treatment of depression.
Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE release. Blockade of heteroreceptors, alpha(2)-receptors contained in serotenergic neurons, enhances the release of 5-HT, increasing the interactions between 5-HT and 5-HT1 receptors and contributing to the anxiolytic effects of mirtazapine. Mirtazapine also acts as a weak antagonist at 5-HT1 receptors and as a potent antagonist at 5-HT2 (particularly subtypes 2A and 2C) and 5-HT3 receptors. Blockade of these receptors may explain the lower incidence of adverse effects such as anxiety, insomnia and nausea. Mirtazapine also exhibits significant antagonism at H1-receptors, resulting in sedation.
Depression, Post traumatic stress diorder (off label), Hot flashes (off label), Insomnia (off label)
Direction to Use
Common Side Effects are Sleepiness, Dryness in mouth, Increased appetite, Headache, Weight gain.