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Dart Tablet is a 5-alpha reductase inhibitor. It blocks an enzyme which is necessary to change testosterone to another hormone that causes the prostate to grow. As a result, it helps to shrink the prostate and relieve the symptoms like difficulty in passing urine.
Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT), which is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor.
Dart is prescribed for the treatment of benign prostatic hyperplasia.
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Common Side Effects are Decreased libido, Decreased semen volume, Impotence.