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Clonil contains Clomipramine as the active ingredient which is a tricyclic antidepressant, used in the treatment of depression and phobic states.
Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. α1-receptor blockage and β-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.
Clonil is used in the treatment of depression and obsessive-compulsive disorder. It is used in patients intolerant of or unresponsive to alternative treatment options for depression.
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Common Side Effects of Clonil are Sleepiness, Blurred vision, Dryness in mouth, Difficulty in urination, Constipation, Orthostatic hypotension (sudden lowering of blood pressure on standing), Weight gain, Increased heart rate.