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Asthalin Respirator Solution contain a racemic mixture of Salbutamol sulphate in equal amounts (50:50) of (R) and (S)-isomers. Salbutamol is a selective beta2-agonist providing short-acting (4-6 hours) bronchodilation with a fast onset (within 5 minutes) in reversible airways obstruction. It is a bronchodilator. It works by relaxing the muscles in the airways and widens airways. This makes breathing easier.
At therapeutic doses, it acts on the beta2-adrenoceptors of bronchial muscle. With its fast onset of action, it is particularly suitable for the management and prevention of attack in asthma.
Each 1 ml contains:
Salbutamol Sulphate IP equivalent to Salbutamol IP- 5 mg
Asthalin Respirator Solution is indicated for use in the routine management of chronic bronchospasm unresponsive to conventional therapy, and in the treatment of acute severe asthma.
Direction to Use
ASTHALIN Respirator Solution 0.5 ml (2.5 mg of salbutamol) should be diluted to a final volume of 2 ml with sterile normal saline. This may be increased to 1 ml (5 mg of salbutamol), diluted to a final volume of 2.5 ml. The resulting solution is inhaled from a suitably driven nebulizer until aerosol generation ceases. When using a correctly matched nebulizer and driving source, this should take about 10 minutes.
ASTHALIN Respirator Solution may be used undiluted for intermittent administration. For this, 2 ml of ASTHALIN Respirator Solution (10 mg of salbutamol) is placed in the nebulizer and the patient allowed to inhale the nebulized solution until bronchodilation is achieved. This usually takes 3-5 minutes. Some adult patients may require higher doses of salbutamol up to 10mg, in which case, nebulization of the undiluted solution may continue until aerosol generation ceases.
The same mode of administration for intermittent administration is also applicable to children. The minimum starting dosage for children below the age of 12 years is 0.5 ml (2.5 mg of salbutamol), diluted to 2-2.5 ml with sterile normal saline. Some children may, however, require higher doses of salbutamol up to 5 mg. Intermittent treatment may be repeated up to four times daily.
ASTHALIN Respirator Solution is diluted with sterile normal saline to contain 50-100 mcg of salbutamol per ml (1-2 ml solution made up to 100 ml with diluents). The diluted solution is administered as an aerosol by a suitably driven nebulizer. The usual rate of administration is 1-2 mg per hour.
In infants below 18 months of age, the clinical efficacy of nebulized salbutamol is uncertain. As transient hypoxaemia may occur, supplemental oxygen therapy should be considered.
Common: Restlessness, Tremor, headache, dizziness, Tachycardia